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目的了解新疆和田地区维吾尔族中老年人尿酸(uric acid,UA)与三酰甘油(triglyceride,TG)关系。方法采取分层抽样和完全随机化方法抽样共选取40岁以上长期居住在新疆和田地区的人群中1 356人,将入选的研究对象先按照性别分为男女两组,再根据高尿酸血症的诊断标准将人群分为UA正常组和高UA组,最后按照UA正常组的三分位数将其分为3个组,从而形成不同UA水平的4个组,使用单因素分析和多因素Logistics回归分析探讨了UA水平与TG之间的关系。结果总体人群中UA水平与TG呈正相关(r=0.165,P<0.01),TG水平均随着UA水平的增加而升高,且高血症患病率升高,有统计学差异(P<0.01);UA水平与其他指标的相关性存在性别差异。UA与TG的单因素分析结果显示:不同性别UA组之间TG水平存在差异,并均有统计学意义(P<0.01)。高三酰甘油血症与UA Logistics回归分析结果示:与女性第一层相比,第二、三、四层患高三酰甘油血症的概率依次增加了1.004倍、1.203倍、2.061倍;男性UA第三、四层较第一层比较,患高三酰甘油血症的概率分别增加了0.809倍、4.232倍,有统计学意义(P<0.05),但男性在第一、二层之间的患病概率比较无统计学意义。上述结果提示UA与高三酰甘油血症具有独立相关,这种现象在女性人群中表现突出。结论新疆和田地区中老年人群UA与TG之间具有相关性,随着UA水平的增加高三酰甘油血症患病风险升高。应预防高尿酸血症,并对危险因素加强综合防控,将会降低高三酰甘油血症患病率,并有利于减少心脑血管疾病意外的发生。
Objective To investigate the relationship between uric acid (UA) and triglyceride (TG) in Uighur middle-aged and elderly people in Hetian area, Xinjiang. Methods By stratified sampling and randomized sampling, a total of 1 356 people over 40 years old who lived in the Hetian area for a long time were selected. The selected subjects were divided into men and women according to gender, then according to hyperuricemia The diagnostic criteria were divided into UA normal group and high UA group, and finally divided into three groups according to the tertile of UA normal group to form four groups with different UA levels. Univariate analysis and multi-factor Logistics Regression analysis explored the relationship between UA levels and TG. Results There was a positive correlation between UA level and TG in the general population (r = 0.165, P <0.01), TG level increased with the increase of UA level, and the prevalence of hyperlipidemia was increased (P < 0.01). There was a gender difference in the correlation between UA level and other indexes. The univariate analysis of UA and TG showed that TG levels differed between UA and UA groups (P <0.01). The results of hypertriglyceridemia and UA Logistics regression analysis showed that the probability of hypertriglyceridemia increased by 1.004 times, 1.203 times and 2.061 times respectively in the second, third and fourth layers compared with the first female; the male UA The third and fourth layers were higher than the first layer, the probability of suffering from hypertriglyceridemia increased by 0.809 times, 4.232 times, statistically significant (P <0.05), but men in the first and second floor between the patients The probability of disease was not statistically significant. These results suggest that UA is independently associated with hypertriglyceridemia, a phenomenon that is most prominent in the female population. Conclusion There is a correlation between UA and TG in middle-aged and elderly people in Hetian area. The prevalence of hypertriglyceridemia increased with the increase of UA level. Should prevent hyperuricemia, and to strengthen the comprehensive prevention and control of risk factors, will reduce the prevalence of hypertriglyceridemia, and is conducive to reducing the incidence of cardiovascular and cerebrovascular accidents.