犬注射国产丁胺卡那霉素15mg/kg,注射后0.7小时可达22.34u/ml的顶峰血药浓度,8小时后为1.0u/ml,静脉注射及肌肉注射其血药浓度-时间变化规律相似。6名健康志愿受试者肌注7.5mg/kg,注射后1小时达20u/ml的顶峰血药浓度,半衰期为2.0小时,主要通过肾脏以原型从尿中排泄。试验并表明国产丁胺卡那霉素与日本产品的体内过程是一致的。 Canine domestic amikacin injection of 15mg / kg, 0.7 hours after injection of up to 22.34u / ml peak plasma concentration, 8 hours after the 1.0u / ml, intravenous and intramuscular injection of plasma concentration - time changes The law is similar. Six healthy volunteers received an intramuscular injection of 7.5 mg / kg and a peak plasma concentration of 20 u / ml one hour after injection with a half-life of 2.0 hours, primarily excreted by the kidneys as a prototype. Tests and showed that domestic amikacin and Japanese products in vivo process is consistent.