论文部分内容阅读
目的:观察乙肝疫苗与乙肝免疫球蛋白联合阻断乙肝病毒母婴垂直传播的临床效果。方法:将HB-sAg阳性孕妇分为三组:分别给予乙肝疫苗联合乙肝免疫球蛋白治疗,乙肝疫苗治疗,及未给予任何治疗。新生儿分为两组,分别给予乙肝疫苗联和乙肝免疫球蛋白治疗,及乙肝疫苗治疗。结果:三组孕妇所生婴儿出生时、12月龄时HBsAg、抗-HBs阳性率差异均有统计学意义(P<0.05)。两组婴儿12月龄时HBsAg、抗-HBs阳性率差异有统计学意义(P<0.05)。结论:联合应用乙肝疫苗和乙肝免疫球蛋白,可有效阻断乙肝病毒母婴垂直传播。
Objective: To observe the clinical effect of hepatitis B vaccine combined with hepatitis B immunoglobulin in blocking the vertical transmission of hepatitis B virus in mother and infant. Methods: HBsAg positive pregnant women were divided into three groups: hepatitis B vaccine combined with hepatitis B immunoglobulin therapy, hepatitis B vaccine treatment, and no treatment was given. Newborns were divided into two groups were given hepatitis B vaccine and hepatitis B immunoglobulin treatment, and hepatitis B vaccine treatment. Results: The positive rates of HBsAg and anti-HBs at 12 months of age at birth were significantly different among three groups of pregnant women (P <0.05). The positive rates of HBsAg and anti-HBs in two groups of infants at 12 months of age were significantly different (P <0.05). Conclusion: The combined application of hepatitis B vaccine and hepatitis B immunoglobulin can effectively block the vertical transmission of hepatitis B virus in mother and infant.