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目的探讨使用孕妇血清游离雌三醇(FE3)和胎盘泌乳素(hPL)检测胎盘功能对慢性胎儿宫内窘迫的诊断价值。方法对612例晚期妊娠(≥32周)孕妇进行胎盘功能检查,用化学发光免疫分析方法测定血清FE3和hPL,其中1项或2项低于正常值者为胎盘功能低下。结果 612例晚期妊娠孕妇经过FE3和hPL检测确定胎盘功能低下组例数31例,无胎盘功能低下组581例;经过临床诊断为慢性胎儿窘迫者43例,无慢性胎儿窘迫569例;胎盘功能低下、慢性胎儿窘迫双阳性者25例。结论 FE3、hPL检测胎盘功能低下对慢性胎儿宫内窘迫有特异性高的诊断价值。
Objective To investigate the diagnostic value of placental function in the diagnosis of chronic fetal distress by using pregnant female serum free estriol (FE3) and placental prolactin (hPL). Methods Placental function tests were performed on 612 pregnant women with advanced pregnancy (≥32 weeks), and serum levels of FE3 and hPL were measured by chemiluminescence immunoassay. One or two of them were lower than the normal values and were placental dysfunction. Results Among the 612 pregnant women with advanced pregnancy, 31 cases with placental dysfunction and 581 cases without placental dysfunction were confirmed by FE3 and hPL test. Among them, 43 cases were diagnosed as chronic fetal distress, 569 cases were without fetal distress, and placental dysfunction , 25 cases of double fetal positive fetal distress. Conclusion FE3, hPL detection of placental dysfunction in chronic fetal distress with high specificity diagnostic value.