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儿童对过量铅暴露损伤血色素特别敏感。红细胞原卟啉是目前作为人类过量铅暴露的最小毒性作用水平指标。本作者对血铅含量较低的婴幼儿,其铅接触水平与原卟啉之间的关系进行了探讨。按照实验设计的条件,在波士顿—产科医院,从11837个出生时进行了脐血血铅测定的婴幼儿中,选择了249个小孩作为本次铅与婴儿生长关系的研究对象,这些婴儿被连续观察两年,每隔半年经手指取血,对血铅(PbB)、红细胞原卟啉(EP)和血细胞容积(Hct)进行一次测定。
Children are particularly sensitive to excessive hemoglobin exposure to lead exposure. Erythrocyte protoporphyrin is currently the indicator of the least toxic effect of exposure to excess lead in humans. This study explored the relationship between lead exposure and protoporphyrin in infants and young children with low blood lead levels. According to the experimental design conditions, at Boston-Maternity Hospital, 249 children were selected as subjects for the study of the relationship between the growth of lead and infants from 11837 babies born at the time of birth, After two years of observation, blood was drawn from the fingers every six months and blood lead (PbB), erythrocyte protoporphyrin (EP), and hematocrit (Hct) were measured.