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醛固酮在体内的生理作用得到阐明以来,目前一般认为醛固酮的增多与高血压症的发病机制,具有一定关系①;在很多类型水肿的形成中(如肝硬化、肾变性、先天性心脏病、妊娠期等),醛固酮也起了一定的作用②。因此,寻找有效的醛固酮的对抗剂,引起不少学者的注意,并也获得若干有效的药物,在上列疾病的治疗中,具有一定意义[③—⑧]。在这类药品中,如Sc9420(Aldactone),价格比较昂贵,用量较
Since the physiological role of aldosterone in the body has been elucidated, aldosterone is generally considered to have an association with the pathogenesis of hypertension (1); in the formation of many types of edema (such as cirrhosis, nephrosis, congenital heart disease, pregnancy Period, etc.), aldosterone also played a role ②. Therefore, looking for effective aldosterone antagonists, attracted many scholars attention, and also to obtain a number of effective drugs, in the treatment of the above diseases, has some significance [③-⑧]. In such drugs, such as Sc9420 (Aldactone), the more expensive, more dosage