志贺毒素(Shigatoxin,Stx)主要由肠出血性大肠杆菌(EHEC)产生,是其主要的致病毒力因子,可通过引起急性肾衰竭导致死亡。迄今为止尚没有可推荐的治疗方案能够有效地预防或治疗Stx引起的疾病。目前,对于Stx的研究热点主要包括:Stx尚未清楚的致病机理研究,Stx与HUS的相关性研究,以及预防、治疗由Stx引起的疾病的研究。本文就以上几方面对国内外的相关研究进行总结及讨论。 Shigatoxin (Stx) is produced mainly by enterohemorrhagic Escherichia coli (EHEC) and is a major virulence factor that can cause death by causing acute renal failure. To date, no recommendable regimen can effectively prevent or treat Stx-induced diseases. At present, the research focuses on Stx include: Stx is not yet clear pathogenic mechanism of study, Stx and HUS correlation studies, and prevention, treatment of Stx-induced diseases. This article summarizes and discusses the related research at home and abroad in the above aspects.