白血病抑制因子(LIF)是一种多功能多生物学活性细胞因子。LIF存在于子宫内膜、妊娠期蜕膜和胎盘上。LIF受子宫内膜雌、孕激素及其他一些因子的严格调控,LIF表达峰值与着床窗时间一致,是着床的关键因子。其能促进体外培养胚胎的胚泡发育与孵化,但LIF对妊娠的维持作用观点还不尽相同,一些研究表明,LIF对妊娠的维持有重要作用,也有的研究表明,LIF不是妊娠维持所必需的。不孕妇女LIF水平较正常妇女要低,因此认为LIF与不孕关系密切。 Leukemia inhibitory factor (LIF) is a multifunctional, biologically active cytokine. LIF exists in the endometrium, decidual decidua and placenta. LIF by the endometrial estrogen and progesterone and other factors strictly regulate the LIF expression peak with the window of the same time, is the key factor in implantation. Some studies have shown that LIF plays an important role in the maintenance of pregnancy. Some studies have shown that LIF is not necessary for the maintenance of pregnancy. Some studies have shown that LIF plays an important role in the maintenance of pregnancy. of. Infertility women LIF levels lower than normal women, so that LIF and infertility are closely related.