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给实验组家兔(n=10)静脉注射二氯化汞(2.5mg/kg),48小时血尿素氮、肾系数都明显高于对照组家兔(n=10),肾脏肿大、色苍白,镜下呈肾近曲小管广泛变性坏死。表明已造成中毒性肾病和急性肾功能衰竭。用硫代巴比妥酸显色法测定血浆过氧化脂质(LPO)浓度,发现实验组LPO 浓度较注射前显著升高(P<0.001),与对照组比较,也显著升高(P<0.001)。提示在二氯化汞引起家兔中毒性肾病和急性肾功能衰竭中,脂质过氧化反应可能参与了二氯化汞引起的肾脏损害过程。
Rabbits in the experimental group (n=10) were given intravenous injection of mercury(II) chloride (2.5 mg/kg). The blood urea nitrogen and renal index at 48 hours were significantly higher than those in the control group (n=10). The kidneys were swollen and colored. Pale, extensive renal degeneration and necrosis of renal proximal tubules. Indicates that toxic nephropathy and acute renal failure have been caused. The thiobarbituric acid method was used to measure the plasma lipid peroxide (LPO) concentration. It was found that the LPO concentration in the experimental group was significantly higher than before the injection (P<0.001), and was also significantly higher than the control group (P< 0.001). It is suggested that the lipid peroxidation may be involved in the process of renal damage caused by mercury dichloride in the toxic toxic nephropathy and acute renal failure caused by mercury dichloride.