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对季戊四醇、三羟甲基乙烷、三羟甲基丙烷、新戊二醇等基于交叉羟醛缩合反应的多元醇类化合物的合成进行对比研究。此类化合物合成的第一步反应均是基于交叉羟醛缩合反应,同时又根据所用碱性催化剂的不同分为钙法、钠法和混合碱法等;而第二步各中间体醛的还原又分为康尼查罗法和催化加氢法。由于催化加氢法具有对环境友好等优点,有逐步取代康尼查罗法的趋势。
The synthesis of polyhydric alcohols based on cross-aldol condensation reactions, such as pentaerythritol, trimethylolethane, trimethylolpropane and neopentyl glycol, was studied. The first step of the synthesis of these compounds are based on cross-aldol condensation reaction, but also according to the different basic catalysts used are divided into calcium, sodium and mixed alkali method; and the second step of the intermediate aldehyde reduction Divided into Conic Charo and catalytic hydrogenation. As the catalytic hydrogenation method has the advantages of being friendly to the environment and the like, there is a trend of gradually replacing Connezalin.