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本文通过直接还原N-烷基化的反应将1,3-二噻烷衍生物导入赖氨酸侧链,合成了两个保护的氨基酸络合剂N~α-Fmoc-N~ε,N~ε-di((2,2-dimethy1-1,3-dithian-5-yl)methyl)-L-lysine(7)及N~α-Fmoc-N~ε-((2,2-dimethyl-1,3-dithian-5-yl)methyl,N~ε-Boc-L-lysine(9)。此保护氨基酸将在多肽化学应用中发挥作用。
In this paper, 1,3-dithiane derivative was introduced into the side chain of lysine by direct reduction N-alkylation reaction, and two protected amino acid complexing agents N ~ α-Fmoc-N ~ ε were synthesized. (2,2-dimethy1-1,3-dithian-5-yl) methyl) -L-lysine (7) and N α -Fmoc-Nε- , 3-dithian-5-yl) methyl, N-ε-Boc-L-lysine (9) This protected amino acid will play a role in the chemical application of the polypeptide.