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高效抗逆转录病毒治疗(Highly Active Anti-retroviral Therapy,HAART)能够有效抑制人类免疫缺陷病毒Ⅰ型(HIV-1)的复制。延缓疾病的临床进展,改善患者的生活质量,大大降低了艾滋病的发病率和死亡率。由于中国大部分HIV/AIDS患者都生活在医疗条件有限的农村地区,基层医疗设备、药物供应及医务人员的技术水平均有限,对农村地区开展HAART更是缺乏经验,由抗逆转录病毒(ARV)药物引起的不良反应颇为常见,因此在治疗过程中,监测和管理因ARV药物引起的不良反应是保证治疗安全性和有效性的关键。该文详细介绍了临床试验研究现场的相关工作经验,探讨其中可以推广并用于国家免费HAART工作的方法和策略。
Highly active anti-retroviral therapy (HAART) effectively inhibits the replication of human immunodeficiency virus type 1 (HIV-1). Delay the clinical progress of the disease, improve the quality of life of the patients and greatly reduce the incidence and mortality of AIDS. As most HIV / AIDS patients in China live in rural areas with limited medical conditions, the technical level of primary medical equipment, drug supply and medical staff are limited. They are inexperienced in developing HAART in rural areas. Anti-retroviruses (ARVs ) Drug-induced adverse reactions are quite common, so monitoring and managing the adverse reactions caused by ARV drugs is the key to ensuring the safety and efficacy of the treatment during treatment. This paper introduces the relevant work experience of clinical trial research site in detail and discusses the methods and strategies which can be promoted and used in the national free HAART work.