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人巨细胞病毒 (HCMV)是人群中广泛存在的感染因子 ,随着免疫力低下人群 (器官移植、恶性肿瘤、艾滋病等 )的增加 ,近 1 0年来 ,HCMV感染引起严重疾病的机制再次成为医学领域的研究热点 ,HCMV几乎可感染人体所有组织 ,整个造血系统尤其是造血祖细胞是 HCMV的主要潜伏部位。通过抑制细胞免疫、诱导细胞凋亡 ,逃避吞噬细胞溶酶体的降解而早潜伏性感染 ,经过转移活化刺激、细胞分化和细胞因子等作用再激活 ,造血系统经常受累 ,其中骨髓抑制、血小板减少和免疫功能紊乱较常见
Human cytomegalovirus (HCMV) is a widespread infection in the population. With the increase of immunocompromised people (organ transplants, malignancies, AIDS, etc.), the mechanism of serious disease caused by HCMV infection has become the focus of medicine again in the past 10 years HCMV can infect almost all tissues of human body. The whole hematopoietic system, especially hematopoietic progenitor cells, is the main latent site of HCMV. Through inhibition of cellular immunity, induction of apoptosis, escape phagocyte lysosomal degradation and latent infection, activation by transfer activation, cell differentiation and reactivation of cytokines, hematopoietic system is often involved, including myelosuppression, thrombocytopenia And immune disorders are more common