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化疗是恶性肿瘤的主要治疗方法之一。随着生命科学的发展,肿瘤综合治疗技术的提高,更多的年轻女性癌症患者得以存活。化疗药物在杀伤肿瘤细胞的同时,对人体正常的组织细胞也具有毒性作用。化疗可导致年轻女性癌症患者卵巢早衰和不孕。现主要概述化疗对卵巢功能的影响,包括化疗导致卵巢早衰、临床监测指标、化疗后的生育能力、机制及预防措施。
Chemotherapy is one of the main treatment of malignant tumors. With the development of life sciences and the improvement of comprehensive cancer treatment technology, more young women with cancer can survive. Chemotherapy drugs kill tumor cells at the same time, the body’s normal tissue cells also have toxic effects. Chemotherapy can lead to premature ovarian failure and infertility in young women with cancer. The main effects of chemotherapy on ovarian function are summarized, including premature ovarian failure caused by chemotherapy, clinical monitoring indicators, fertility after chemotherapy, mechanism and preventive measures.