主要由细胞角蛋白构成的中间丝系统对维持肝脏细胞的结构与功能完整具有重要作用。在胚胎肝发生过程中细胞角蛋白表型可以发生转化 ,然而在乙型肝炎及肝硬变、肝损伤等肝脏疾病 ,尤其是肝脏肿瘤中 ,肝细胞细胞角蛋白表达也出现很大的异质性 ,表明肝脏细胞中所含的细胞角蛋白并不是固定不变的 ,在一定条件下 ,可以相互转化。因此细胞角蛋白作为细胞标志物 ,其表达的异常改变在肝脏疾病诊断中具有重要的应用价值。 The intermediate filament system, which is mainly composed of cytokeratins, plays an important role in maintaining the integrity of the structure and function of liver cells. Cytokeratin phenotypes can be transformed during the development of embryonic liver. However, in hepatic diseases such as hepatitis B, cirrhosis and liver injury, hepatocellular cytokeratin expression is also highly heterogeneous Sexual, indicating that the cytokeratin contained in liver cells is not fixed, under certain conditions, can be transformed into each other. Therefore, cytokeratin as a cell marker, abnormal expression of its expression in the diagnosis of liver disease has an important value.