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内毒素是固紫阴性杆菌细胞壁的组成部分,在正常情况下,内毒素经胃肠道吸收进入门脉血后,被肝脏的网状内皮细胞清除。当肝脏严重损害或显著门脉高压时,虽无感染存在,内毒素可以在腹水或体循环中发现。作者对46例证明有食管静脉曲张的肝硬化,采用鲎测定法(LimuIus assay)检测血浆和腹水的内毒素。分成两组:腹水组29例,无腹水组17例。另外,慢性进行性肝炎12例作为对照。血浆内毒素阳性在腹水组有22例(75.9％),无腹水组4例(23.5％),两组差异非常显著(P<0.01)。腹水组中,腹水内毒素阳性23例(79.3％),其中17例内毒素滴度≥10~(-3)
Endotoxin is an integral part of the cell wall of solid-violet-negative bacilli. Under normal conditions, endotoxin is absorbed into the portal blood by the gastrointestinal tract and is cleared by the reticuloendothelial cells of the liver. When the liver is severely damaged or has significant portal hypertension, endotoxin can be found in ascites or the systemic circulation, although no infection is present. The authors of 46 cases of cirrhosis confirmed esophageal varices, using Limulus assay (LimuIus assay) detection of plasma and ascites endotoxin. Divided into two groups: ascites group 29 cases, 17 cases without ascites group. In addition, chronic progressive hepatitis in 12 cases as a control. Plasma endotoxin positive in ascites group 22 cases (75.9%), no ascites group 4 cases (23.5%), the difference between the two groups was significant (P <0.01). Ascites group, ascites endotoxin positive in 23 cases (79.3%), of which 17 cases of endotoxin titers ≥ 10 ~ (-3)