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目的探讨早期使用小剂量氨茶碱对早产儿智能发育的影响。方法选取新出生的日龄<1 d的早产低出生体重儿100例,将其随机分为用药组及对照组,每组各50例,用药组氨茶碱首剂4 mg/kg,维持量2 mg/kg,12 h/次,连续使用5~7 d,对照组不使用氨茶碱,从孕周计算纠正胎龄满40周时两组均采取医护指导与家庭干预相结合的模式,随访比较两组早产儿的智能发育情况。结果经CDCC量表测定比较发现在纠正胎龄后第6、12、18及24个月龄时,用药组早产儿的智力发育指数(MDI)及运动发育指数(PDI)均高于对照组(P<0.05);Gesell发育量表检测,用药组早产儿在大运动、精细动作、语言、个人-社交和适应性方面均明显优于对照组(P<0.05)。结论早期使用小剂量氨茶碱对心肺功能均正常的早产儿智能发育有一定改善作用,无明显不良反应。
Objective To investigate the effect of early use of low-dose aminophylline on the intellectual development of premature infants. Methods 100 newborns with low birth weight preterm birth on day <1 d were selected and randomly divided into two groups, 50 cases in each group, the first dose of aminophylline 4 mg / kg, the maintenance dose 2 mg / kg, 12 h / time, continuous use of 5 ~ 7 d, the control group did not use aminophylline, gestational age correction of gestational age 40 weeks, both groups take medical guidance and family intervention combined mode, Follow-up comparison of intelligence development of preterm infants in both groups. Results The results of CDCC showed that the mental development index (MDI) and motor development index (PDI) of premature infants at 6th, 12th, 18th and 24th month after correction of gestational age were higher than those of the control group P <0.05). The Gesell developmental scale test showed that the preterm infants in the medication group were significantly better than the control group in large movement, fine motor, language, personal-social and adaptability (P <0.05). Conclusion Early use of low-dose aminophylline can improve the intelligence development of premature infants with normal heart and lung function without obvious adverse reactions.