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目的遵循2009年国际事件相关电位(event-related potentials,ERPs)指南,获取不同年龄组儿童听觉ERPs外源性反应电位主要波形潜伏期及波幅正常值,总结儿童听觉ERPs外源性反应电位发育规律和临床应用前景。方法收集2008-2010年156名儿童与成人(儿童来源于重庆医科大学附属儿童医院儿童保健科门诊,骨科、普外科、呼吸及消化科呼吸道感染及消化道感染恢复期的住院患儿,成人为重庆医科大学健康在读大学生),分为3~5、>5~7、>7~9岁和>9~17岁组,以及22~29岁青年成人组。采用经典的“Oddball”模式进行听觉ERPs检测,每名受试者均进行2次以上测试,以判断波形的重复性。电位仪分别显示靶刺激和非靶刺激下ERPs叠加后图形,对ERPs各外源性成分P1、N1、P2和N2波形测量,包括波潜伏期及波幅。结果靶刺激或非靶刺激诱发的外源性电位潜伏期均随年龄增长非匀速地成熟性缩短。无论靶刺激或非靶刺激,各年龄组的所有外源性电位波潜伏期均值中,95%以上都在2SD范围内。除N1波外,靶刺激下P1、P2、N2波幅随年龄增加呈先增高后降低趋势,成人和青少年期波幅反较儿童期低(P<0.05)。非靶刺激下,95%的健康成人甚至不能引出N2波形。所有外源性电位波幅均值皆伴有较大标准差,提示存在明显个体差异性。结论 ERPs外源性电位各波潜伏期同样随年龄规律性缩短,靶刺激较非靶刺激有更恒定的检测结果,可直接反映颞叶初级听觉皮层功能,且不受患者合作程度影响。
Objective To follow the guideline of international event-related potentials (ERPs) in 2009, to obtain the main waveform excursion and normal amplitude of exogenous response potential of auditory ERPs in children of different ages, and to summarize the development rules of exogenous response potential of auditory ERPs in children and Clinical application prospects. Methods A total of 156 children and adults (children from Chongqing Children’s Hospital Affiliated to Chongqing Children’s Hospital Clinic, Orthopedics, General Surgery, Respiratory and Gastroenterology Respiratory Tract Infections and Respiratory Tract Infections were collected from 2008 to 2010. The adults were Chongqing Medical University health undergraduates), divided into 3 to 5,> 5 to 7,> 7 to 9 years old and> 9 to 17 years old group, and 22 to 29 years old young adult group. Auditory ERPs were tested using the classical “Oddball” mode, with each subject performing more than 2 tests to determine the repeatability of the waveform. Potentiometers display the superimposed ERPs of target stimulus and non-target stimuli, respectively. The waveforms of P1, N1, P2 and N2 of exogenous components of ERPs including the latency and amplitude of wave were measured. Results The latent period of exogenous potential induced by target or non-target stimulation both shortens with non-uniform maturation. Regardless of the target stimulus or the non-target stimulus, 95% of the mean exogenous latency latency values for all age groups were in the 2SD range. In addition to N1 wave, the amplitude of P1, P2 and N2 increased firstly and then decreased with the increase of age, and the amplitude of adult and adolescent was lower than that of childhood (P <0.05). Under non-target stimulation, 95% of healthy adults can not even lead to N2 waveforms. All exogenous potential amplitude amplitude are accompanied by a larger standard deviation, suggesting significant individual differences exist. Conclusions The latent period of exogenous potentials of ERPs also decreases with the regularity of age, and the target stimulus has a more constant detection result than the non-target stimuli, which can directly reflect the primary auditory cortex function of temporal lobe and is not affected by the degree of patient cooperation.