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树突状细胞是功能最强的抗原提呈细胞,是启动、调节及维持免疫应答的核心环节,以树突状细胞为基础的肿瘤疫苗被认为是最具潜能的肿瘤免疫治疗手段。细胞因子信号通路抑制因子1(suppressor ofcytokine signaling1,SOCS1)是细胞因子信号通路抑制因子(suppressor of cytokine signaling,SOCS)家族的重要成员,广泛参与树突状细胞的发生、成熟和活化,具有负调控树突状细胞功能的重要作用。SOCS1沉默的树突状细胞能够促进自身成熟并增强其诱导的T细胞的抗肿瘤活性。现就国内外关于树突状细胞功能研究及基因修饰的肿瘤疫苗临床试验作一综述,以期对未来的研究有所帮助。
Dendritic cells are the most potent antigen-presenting cells and the core of the immune response. The dendritic cell-based tumor vaccine is considered to be the most potential tumor immunotherapy. The suppressor of cytokine signaling1 (SOCS1) is an important member of the family of suppressor of cytokine signaling (SOCS), which is widely involved in the generation, maturation and activation of dendritic cells. It has negative regulation Dendritic cell function plays an important role. SOCS1-silenced dendritic cells promote self-maturation and enhance the antitumor activity of their induced T cells. Now on the domestic and international research on the function of dendritic cells and gene modification of tumor vaccine clinical trials are reviewed, with a view to future research is helpful.