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目的:观察糖脉康颗粒联合卡托普利治疗糖尿病肾病(DN)的临床疗效。方法:160例患者随机分为观察组和对照组,对照组接受卡托普利治疗,25 mg/次,3次/d;观察组接受糖脉康颗粒治疗,5 g/次,3次/日,同时服用卡托普利25 mg/次,3次/d。治疗4周后,观察患者SUN,SCr,24 h尿蛋白的变化。结果:两组患者BUN,SCr,24 h尿蛋白定量在治疗前无显著性差异。治疗4周后,观察组与同组治疗前相比,疗效有显著性差异(P<0.05);对照组与同组治疗前相比,24 h尿蛋白定量有显著性差异外(P<0.05),BUN,SCr虽有所改善,但无统计学意义;治疗后两组相比,效果有显著性差异(P<0.05)。结论:糖脉康颗粒联合卡托普利治疗DN效果优于单纯应用卡托普利。
Objective: To observe the clinical effect of Tangmaikang granule combined with captopril in the treatment of diabetic nephropathy (DN). Methods: 160 patients were randomly divided into observation group and control group, the control group received captopril, 25 mg / time, 3 times / d; observation group received Tang Mai Kang particles treatment, 5 g / times, 3 times / Day, taking captopril 25 mg / time, 3 times / d. After 4 weeks of treatment, the changes of urinary protein in 24 hours were observed in patients with SUN, SCr. Results: The urinary protein of BUN, SCr and 24 h in two groups had no significant difference before treatment. After 4 weeks of treatment, the curative effect of the observation group was significantly different from that of the same group before treatment (P <0.05), while the control group had a significant difference in 24-hour urine protein (P <0.05) ), BUN and SCr were improved, but there was no significant difference between the two groups after treatment (P <0.05). Conclusion: Tangmaikang granule combined with captopril treatment of DN better than the simple application of captopril.