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目的探讨中国山东省沿海地区汉族男性群体的白细胞介素23受体(IL-23R)基因rs7517847位点G/T的多态性是否与痛风的易感性有关。方法选取202例痛风患者和346例健康对照者,检测中国汉族男性群体的IL-23受体内含子区rs7517847位点基因多态性分布,数据经χ2检验得出其与痛风发病的遗传易感性的关系。结果经χ2检验,痛风组和对照组中IL-23R基因rs7517847位点GG,GT和TT基因型频率(10.4%,49.5%,40.1%;16.2%,49.7%,34.1%;χ2=4.305,P>0.05)与等位基因频率G和T(35.1%,41%;64.9%,59%;χ2=3.727,P>0.05)均无统计学意义。IL-23R基因rs7517847位点G/T基因多态性与痛风病的危险因素无显著性关联。结论尚不能认为中国沿海地区汉族男性人群中IL-23R内含子区rs7517847位点基因多态性与痛风有关联性。
Objective To investigate whether G / T polymorphism of rs7517847 of IL-23R gene in Chinese male Han population in Shandong province of China is related to the susceptibility to gout. Methods Totally 202 gout patients and 346 healthy controls were selected to detect the distribution of rs7517847 polymorphism in the IL-23 receptor in Chinese Han male population. The data were analyzed byχ2 test and the genetic susceptibility to gout Sensual relationship. Results The frequencies of GG, GT and TT genotypes of rs7517847 of IL-23R gene in gout group and control group were 10.4%, 49.5%, 40.1%, 16.2%, 49.7%, 34.1% and 2χ 4.305, respectively > 0.05) and allele frequency G and T (35.1%, 41%; 64.9%, 59%; χ2 = 3.727, P> 0.05). There was no significant correlation between the G / T polymorphism of IL-23R rs7517847 and the risk factors of gout. Conclusion It is not yet known that the genetic polymorphism of rs7517847 in IL-23R intron region of Han nationality in China’s coastal areas is associated with gout.