该研究改进了现行脊髓灰质炎糖丸疫苗的稳定性，由１ｍｏｌ·Ｌ－１ＭｇＣｌ２稳定性改为１ｍｏｌ·Ｌ－１ＭｇＣｌ２＋０．５ｍｏｌ·Ｌ－１磷酸盐缓冲液复合稳定剂（１ｍｏｌ·Ｌ－１ＭｇＣｌ２＋０．５ｍｏｌ·Ｌ－１ＰＢ）．采用复合稳定剂后，大大增加了疫苗的稳定性．２２℃保存时间比１ｍｏｌ·Ｌ－１ＭｇＣｌ２稳定剂延长了一周，即保存时间从１２ｄ延长至１８～２１ｄ．疫苗于４℃保存了６个月，滴度降低甚微．在３７℃保存３ｄ，疫苗的滴度降仍符合ＷＨＯ规程的要求 This study improved the stability of the current polio vaccine by changing the stability of 1 mol·L-1 MgCl 2 to 1 mol·L-1 MgCl 2 + 0.5 mol·L -1 phosphate buffered saline (1 mol·L -1 MgCl 2 O +). 5mol · L-1PB). The use of composite stabilizer, greatly increased the stability of the vaccine. 22 ℃ storage time than 1mol · L-1MgCl2 stabilizer extended for a week, that is preserved from 12d extended to 18 ~ 21d. The vaccine was stored at 4 ° C for 6 months with little reduction in titer. After 3 days of storage at 37 ° C, the drop in titer of the vaccine still meets the requirements of WHO regulations