【摘 要】
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Enterovirus 71,belonging to human enterovirus species A in the genus Enterovirus of the family Picoaviridae,is one of the main causative agents of hand-foot-mou
【机 构】
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Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya
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Enterovirus 71,belonging to human enterovirus species A in the genus Enterovirus of the family Picoaviridae,is one of the main causative agents of hand-foot-mouth disease.It can also cause severe neurological diseases such as acute encephalitis,polio-like paralysis,and neurogenic pulmonary edema,and it has become a serious public health conce especially in the Asia-Pacific region.Native virions of enteroviruses are composed of a positive-stranded RNA genome and 60 copies of each capsid protein;namely VP1,VP2,VP3 and VP4.The natural lipid called "pocket factor" is harbored in the hydrophobic pocket of the VP1 capsid protein and plays an important role in stabilizing the native virion structure.Enterovirus infection is initiated by the binding of virions to their respective receptors followed by their intealization into the cells.
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