一般认为晚期肝脏纤维化是不可逆的。作者以日本血吸虫感染兔研究其可逆性取得明显效果。用日本株日本血吸虫尾蚴感染雄兔12只,于感染后20,40和60周进行肝活检,取5g肝脏组织分3份:一份浸于液氮,一份制成肝脏碎片,另有一份以福马林固定。液氮中的样品用于游离脯氨酸、胶原蛋白羟脯 It is generally believed that advanced liver fibrosis is irreversible. The authors of rabbit infection with rabbit schistosoma japonica reversibility achieved significant results. Twelve male rabbits were infected with the Japanese strain of Schistosoma japonicum cercariae. Liver biopsies were taken at 20, 40 and 60 weeks after infection. Five g liver tissues were divided into three groups: one was immersed in liquid nitrogen, one was made into liver fragments, and the other one Fusulin fixed. Samples in liquid nitrogen are used for free proline, collagen prolactin