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随着低剂量阿司匹林（LDA）在心脑血管疾病一级预防及二级预防中的广泛应用，LDA相关上消化道损伤的发病率逐年增加。质子泵抑制剂（ PPI）能够有效预防 LDA相关的上消化道损伤，但长期应用PPI的不良反应、价格及其与氯吡格雷的相互作用，使PPI的预防作用受到质疑。传统的抑酸药物H2受体拮抗剂（ H2 RA）再次受到关注。该文就H2 RA对LDA相关上消化道损伤的预防效果及与PPI的疗效比较予以综述。“,”With the widely use of low-dose aspirin(LDA) in the primary and secondary prevention of cardiovascular and cerebrovascular diseases,the incidence of LDA associated upper gastrointestinal injuries increases year by year.Proton pump inhibitors( PPI) have been improved to be effective to prevent the occur-rence of LDA associated gastrointestinal injury,though the prevention effect of PPIs has been questioned for their adverse reactions,price and interactions with clopidogrel.Histamine 2 receptor antagonists(H2RA),the traditional acid suppression drugs,has gained attentions again.Here is to make a review of H2RA in the pre-vention of LDA associated gastrointestinal injuries and comparison with PPI′s effect.