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目的:分析基底细胞癌中P53蛋白的表达情况,探讨P53蛋白的表达与基底细胞癌发生发展的关系,以及在基底细胞癌发病机制中的作用。方法:选取2006年7月至2007年2月,北京朝阳医院皮肤科手术切除的基底细胞癌及正常皮肤组织石蜡标本各17例,免疫组织化学法分析P53蛋白在基底细胞癌和正常皮肤组织中的表达情况。结果:17例基底细胞癌中P53蛋白的表达率为100%。综合染色强度和阳性细胞所占比例进行平均半定量分析,P53蛋白在基底细胞癌中表达程度为,而在正常皮肤组织中表达程度为+,两者之间存在统计学上显著性差异。结论:P53在基底细胞癌中呈现高度表达状态,提示P53蛋白的表达与基底细胞癌的发病过程关系密切,可能在其发生发展过程中起重要作用。
OBJECTIVE: To analyze the expression of P53 protein in basal cell carcinoma and to explore the relationship between the expression of P53 protein and the occurrence and development of basal cell carcinoma and its role in the pathogenesis of basal cell carcinoma. Methods: From July 2006 to February 2007, 17 cases of basal cell carcinoma and normal skin tissue paraffin-embedded specimens from dermatology department of Beijing Chaoyang Hospital were selected. The expression of P53 protein in basal cell carcinoma and normal skin tissue were analyzed by immunohistochemistry The expression of the situation. Results: The expression of P53 protein in 17 cases of basal cell carcinoma was 100%. The average staining intensity and the proportion of positive cells for semi-quantitative analysis of the average, P53 protein expression in basal cell carcinoma was, while in normal skin tissue expression was +, there was a statistically significant difference between the two. Conclusions: P53 is highly expressed in basal cell carcinoma, suggesting that the expression of P53 is closely related to the pathogenesis of basal cell carcinoma and may play an important role in the development and progression of basal cell carcinoma.