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当前针对小儿支气管哮喘的防治问题,主要是采用药物的对症治疗及抗过敏制剂治疗(包括特异性和非特异性)。我科自1982年以来采用口服脊髓灰质炎糖丸防治小儿支气管哮喘,并且进行了长期随访,取得了初步疗效。现将随访1年以上的30例临床资料进行了分析。7岁以前发病26例占86.6%,符合哮喘多自幼年发病的一般规律。病情分型以中、重型(共计24例占80%)为多.且病程较长,>5年16例。30例中有28例有典型的夜间发作史占93.3%,有个人过敏史者14例占46.7%,有家族过敏史者15例占50%。全部病例于治疗前均作了免疫球蛋白检查,IgE 升高者26例占86.7%。我们采用北京市防疫站投放之脊髓灰质炎减毒活疫苗糖丸口服,经治疗30例中29例有效占96.7%,其中21例作了IgE 治疗前后对照,15例治疗后IgE 直下降,占71.4%,平均值由1993IU/ml 下降1168IU/ml。本文重点探讨了采用口服脊髓灰质炎疫苗(OPV)防治小儿支气管哮喘的疗效,并对其治疗原理进行了初步分忻。认为口服OPV 治疗小儿支气管哮喘有效、简便、无痛苦、安全、无毒副作用等优点,虽然远期疗效尚不理想,也是值得推广的一种防治方法。
The current prevention and treatment of bronchial asthma in children, mainly the use of drug symptomatic treatment and anti-allergy treatment (including specificity and non-specific). Our department has used oral polio candy to prevent and treat bronchial asthma in children since 1982, and has carried on the long-term follow-up and obtained the preliminary curative effect. Now follow-up more than 1 year of 30 cases of clinical data were analyzed. 26 cases before the age of 7 accounted for 86.6%, in line with the general rule of childhood asthma and more. Type of disease in the medium and heavy (a total of 24 cases accounted for 80%) for more and longer duration,> 5 years in 16 cases. Of the 30 patients, 28 had a typical nocturnal episode of 93.3%, 14 had a personal allergy, 46.7%, and 15 had a family history of allergy, 50%. All cases were immunoglobulin before treatment, 26 cases of elevated IgE accounted for 86.7%. We use the Beijing Municipal Epidemic Prevention Station live attenuated polio vaccine putting oral administration of oral treatment of 29 cases of 29 cases accounted for 96.7% effective, of which 21 cases were treated with IgE before and after treatment, 15 cases of IgE after treatment decreased, accounting for 71.4%, with an average decrease of 1168 IU / ml from 1993 IU / ml. This article focuses on the use of oral polio vaccine (OPV) in the prevention and treatment of bronchial asthma in children, and its treatment principle preliminary analysis. Oral OPV treatment of children with bronchial asthma is considered effective, simple, painless, safe, non-toxic side effects and other advantages, although the long-term efficacy is not ideal, but also worth promoting a prevention and treatment methods.