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英国Cortecs公司资助剑桥大学研制经鼻或口腔接种的新型粘膜疫苗.Cortecs疫苗发现中心将开发Page等研究成果,把乳酸乳杆菌用作抗多种感染因子的疫苗的载体.Cortecs公司认为,这种发现于酸乳和其他食品中的良性环境菌,是一种比目前使用的细菌(如大肠杆菌)更安全有效的载体.乳杆菌为革兰阳性菌,而大肠杆菌和其他常用菌属革兰阴性菌.源于革兰阳性菌的重组基因插入革兰阴性菌后往往不稳定.研究组的第一个目标是开发肺炎球菌菌苗,肺炎球菌为革兰阳性菌,是一个重要的卫生保健问题.此菌可引起儿童中耳炎,推测80%的儿童在3岁前感染过此菌.
Cortecs, a UK-based company funded by Cambridge University to develop a nasal or oral vaccination of the new mucosal vaccine.Cortecs Vaccine Discovery Center will be developed Page and other research results, the use of Lactobacillus Lactobacillus as a variety of infectious agents against the vaccine vector.Cortecs that such Found in yogurt and other food in the benign environment bacteria, is a more efficient than the currently used bacteria (such as E. coli) vector.Lactobacillus is Gram-positive bacteria, and E. coli and other commonly used genus Gram Negative bacteria. Gram-positive bacteria derived from recombinant genes inserted into Gram-negative bacteria often instability. The first goal of the study group is to develop pneumococcal vaccine, pneumococcal Gram-positive bacteria, is an important health care This bacteria can cause otitis media in children, presumably 80% of children infected with the bacteria before the age of 3.