Cloven hoof animals have been a major source of nutritious animal protein for humans for at least 10000 years. Over this time many were domesticated into livestock and some were put under selection for traits of importance or cultural preference. Accompanying domestication, diseases were transmitted from livestock to humans as a result of living in close quarters. Eight of 15 major chronic, temperate diseases, including diphtheria, influenza A, measles, mumps, pertussis, rotavirus, smallpox, tuberculosis, are thought to have reached humans from domestic animals (Wolfe et al. 2012). The list may be longer since only those with pandemic potential become evident. The toll on humans resulting from viruses moving from livestock to people is enormous. For instance, the United States Centers for Disease Control and Prevention (CDC) estimates that influenza, which periodically emerges from swine and birds, annually has resulted in 9–45 million illnesses, 140000– 810000 hospitalizations and 12000–61000 deaths, depending on the year (CDC 2020). The estimated cost today of influenza is greater than $25 billion per year (Molinari et al. 2007, adjusted for inflation). The costs to farmers of viral infections in livestock can be even larger.