吡喹酮(Praziquantel)是近年发现的广谱抗寄生虫新药。经许多国家试用,证明具有低毒、高效、速效、疗程短等优点。国内于1977年合成此药,先后进行了抗血吸虫病,抗绦虫、囊虫、中华分支睾吸虫和肺吸虫病的研究,均取得较好的进展。本文简介吡喹酮的杀血吸虫作用机制和药物代谢研究进展,以利于合理用药和新药 Praziquantel (Praziquantel) is a new broad-spectrum anti-parasitic drug discovered in recent years. Proved by many countries, it has the advantages of low toxicity, high efficiency, quick response and short course of treatment. Domestic synthesis of this medicine in 1977, has conducted anti-schistosomiasis, anti-tapeworm, cysticercosis, Clonorchis sinensis and paragonimiasis research, have made good progress. This article describes the praziquantel killing mechanism of schistosomiasis and drug metabolism in order to facilitate the rational use of drugs and new drugs