论文部分内容阅读
目的探讨妊娠梅毒快速血浆反应试验(RPR)滴度与妊娠不良结局的关系。方法经梅毒螺旋体颗粒凝集试验(TPPA)筛查,对妊娠合并梅毒患者共192例孕母分娩前外周血检测RPR滴度,分析妊娠不良结局,比较孕期抗梅毒治疗组(162例)与未治疗组(30例)妊娠并发症及新生儿不良结局发生率。结果随着孕母RPR滴度的升高,畸形、死胎、早产、先天性梅毒及新生儿死亡的风险升高。孕母RPR滴度≥1∶8时早产、新生儿畸形和先天性梅毒发生率高于RPR滴度≤1∶4者(P<0.05)。未治疗组新生儿畸形、先天性梅毒和死胎发生率高于治疗组(P<0.05)。结论随着孕母RPR滴度的升高,妊娠不良结局风险升高;抗梅毒治疗能明显改善合并梅毒患者的妊娠结局。
Objective To investigate the relationship between rapid pregnancy test (RPR) titer of pregnancy syphilis and poor pregnancy outcome. Methods Totally 192 pregnant women with syphilis during pregnancy were tested for RPR titer by TPPA. The RPR titers were measured before delivery and the adverse pregnancy outcomes were analyzed. Compared with untreated anti-syphilis treatment group (162 cases) Group (30 cases) pregnancy complications and neonatal adverse outcomes. Results With the increase of pregnant RPR titer, the risk of deformity, stillbirth, premature delivery, congenital syphilis and neonatal death increased. The preterm birth, neonatal deformity and congenital syphilis were higher in pregnant women with RPR titer> 1: 8 than those with RPR titer <1: 4 (P <0.05). The incidence of neonatal malformation, congenital syphilis and stillbirth in the untreated group was higher than that in the untreated group (P <0.05). Conclusions With the increase of RPR titer of pregnant women, the risk of adverse outcome of pregnancy increases; anti-syphilis treatment can significantly improve pregnancy outcomes in patients with syphilis.