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目的：探讨新生儿呼吸窘迫综合征患儿机械通气相关护理的临床效果。方法：通过对2013年5月至2015年5月在我院应用机械通气治疗的55例呼吸窘迫综合征患儿给予综合护理（实验组），同期在我院行机械通气治疗的55例呼吸窘迫综合征实施常规护理（对照组），观察比较两组患儿通气时间、治疗前后SpO2、住院时间差异。结果：实验组患儿通气时间和住院时间同对照组明显缩短，治疗后SpO2明显提高，差异具有统计学意义（P<0.05）。结论：针对应用机械通气治疗的呼吸窘迫综合征患儿采用综合护理可缩短治疗时间，提高治疗效果，促进患儿康复，值得推广应用。“,”Objective To study the neonatal respiratory distress syndrome in children with mechanical ventilation related nursing clinical effect.Methods In May 2013 to May 2015 in our hospital used mechanical ventilation treatment of 55 cases of children with respiratory distress syndrome gives comprehensive nursing (experimental group), in the same period in our line of mechanical ventilation treatment of 55 cases of respiratory distress syndrome (control group) and conventional nursing observation time, before and after treatment, compared two groups of children with ventilation SpO2, length of hospital stay.Results The experimental group with ventilation time and with the control group obviously shorten the hospitalization time, SpO2improved obviously after treatment, the difference statistically significant (P < 0.05).Conclusion In view of the application of mechanical ventilation treatment of children with respiratory distress syndrome adopt comprehensive nursing can shorten the treatment time, improve the effect of treatment, promote patients recover, is worthy of popularization and application.