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目的 探讨血清血管内皮生长因子在肺癌诊断、预后及疗效观察中的意义。方法 用双抗夹心ELISA方法测定 5 0例肺癌患者血清的VEGF水平 ,另用 4 0名健康人作对照。用SPSS 10 .0统计软件包进行统计分析。结果 肺癌患者血清VEGF水平显著高于健康人 (P <0 .0 0 1) ;晚期肺癌 (Ⅲ期、Ⅳ期 )患者血清VEGF水平高于早期肺癌 (Ⅰ期 ,Ⅱ期 )患者 ,差异有显著性 (P <0 .0 1) ,有淋巴结转移者高于无淋巴结转移者 (P <0 .0 5 )。结论 血清VEGF可能成为肺癌的一个新的肿瘤标志物 ,用于肺癌的诊断和动态监测病情进展、预后判断。
Objective To investigate the significance of serum vascular endothelial growth factor in the diagnosis, prognosis and curative effect of lung cancer. Methods Serum levels of VEGF in 50 lung cancer patients were determined by double-antibody sandwich ELISA. Another 40 healthy people were used as controls. Statistical analysis was performed using the SPSS 10.0 statistical package. Results The serum level of VEGF in lung cancer patients was significantly higher than that in healthy people (P <0.01). The serum VEGF levels in patients with advanced lung cancer (stage Ⅲ and Ⅳ) were significantly higher than those in patients with early stage lung cancer (stage Ⅰ and Ⅱ) (P <0.01), those with lymph node metastasis were higher than those without lymph node metastasis (P <0.05). Conclusions Serum VEGF may be a new tumor marker for lung cancer, which is used to diagnose lung cancer and monitor its progression and prognosis dynamically.