大脑组胺的功能包括调节神经内分泌系统、饮水行为、睡眠-觉醒周期和进食行为。目前已发现4种组胺受体:H1,H2,H3和H4。H1受体定位在突触后,主要存在于下丘脑、大脑皮质、前脑基底层和边缘系统。H1和H3对于进食行为的调节非常重要,H1受体激动剂和H3受体拮抗剂会减少啮齿类动物的 Functions of brain histamine include regulating neuroendocrine system, drinking behavior, sleep-wake cycle and eating behavior. Four histamine receptors have been found so far: H1, H2, H3 and H4. H1 receptors are located post-synaptically, mainly in the hypothalamus, cerebral cortex, basal forebrain and limbic system. H1 and H3 are important for the regulation of eating behavior, and H1 receptor agonists and H3 receptor antagonists reduce rodent