新生儿高胆红素血症为临床常见疾病,经过光疗等治疗大多可治愈,但重症高胆红素血症一旦形成,重者危及生命,幸存者亦可能留有永久的神经系统后遗症。其常见病因包括母婴血型不合溶血病、感染、红细胞酶缺陷、红细胞增多症、出血、甲状腺功能减退等,其中不明原因高胆红素血症约占五分之一[1-2]。随着分子生物学快速发展,目前研究集中于 Neonatal hyperbilirubinemia is a common clinical disease. Most of the treatment after phototherapy can be cured. However, severe hyperbilirubinemia can form a serious risk to human life and the survivors may also have permanent neurological sequelae. Common causes include maternal and child incompatible hemolytic disease, infection, erythrocyte enzyme deficiency, polycythemia, hemorrhage, hypothyroidism, etc., of which unexplained hyperbilirubinemia accounts for about one-fifth [1-2]. With the rapid development of molecular biology, the current research focuses on