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目的分析和研究硝酸甘油与酚妥拉明治疗妊娠高血压危象效果。方法我们选取2010年2月-2012年10月妊娠期高血压危象患者78例,将其按双盲随机方法分为观察组(39例)与对照组(39例)。对照组患者临床给予酚妥拉明治疗;观察组患者临床给予硝酸甘油治疗,将两组患者治疗后的血压变化情况进行对比。结果两组患者治疗1小时后的收缩压、舒张压检测值明显低于治疗前(P<0.05),具有统计学意义。治疗后收缩压组间相比没有明显的差异(P>0.05),无统计学意义。观察组患者治疗后的舒张压检测值明显低于对照组(P<0.05),具有统计学意义。结论酚妥拉明与硝酸甘油应用于妊娠期高血压危象患者的治疗中,降压效果均比较明显,两种药物起效较快速,并且患者在服用药物治疗期间没有出现明显的不适反应,安全性较强,硝酸甘油的降低舒张压效果更佳。
Objective To analyze and study the effect of nitroglycerin and phentolamine in treating hypertensive crisis of pregnancy. Methods We selected 78 patients with hypertensive crisis during pregnancy from February 2010 to October 2012 and divided them into observation group (39 cases) and control group (39 cases) according to the double-blind randomized method. Patients in the control group were treated with phentolamine clinically; patients in the observation group were given nitroglycerin clinically, and blood pressure changes after treatment were compared between the two groups. Results After 1 hour of treatment, the systolic blood pressure and diastolic blood pressure were significantly lower in both groups than those before treatment (P <0.05), which were statistically significant. Systolic blood pressure after treatment there was no significant difference between groups (P> 0.05), no statistical significance. The observation group’s diastolic blood pressure after treatment was significantly lower than the control group (P <0.05), with statistical significance. Conclusion In the treatment of patients with hypertensive crisis of pregnancy, the effect of phentolamine and nitroglycerin is obvious. The two drugs have a rapid onset of action, and the patients did not have obvious discomfort reaction during medication. More secure, nitroglycerin to reduce diastolic blood pressure better.