目的探讨血清降钙素原(PCT)检测联合APACHE Ⅱ评分对脓毒症病情及预后的价值。方法对长沙市第四医院重症医学科68例脓毒症患者按疾病的严重程度分为脓毒症组、严重脓毒症组、脓毒性休克组,分别检测各组血清PCT,并同时进行APACHE Ⅱ评分,对PCT与APACHE Ⅱ进行相关性分析。然后再根据患者转归不同分为生存组和死亡组,评价PCT、APACHE Ⅱ评分对脓毒症预后的判断的指导价值。结果脓毒症组PCT低于严重脓毒症组,严重脓毒症组PCT低于脓毒性休克组,其差异均具有统计学意义(P<0.05),死亡组PCT及APACHE Ⅱ评分明显高于生存组,差异具有统计学意义(P<0.05)。结论脓毒症患者PCT水平与APACHE Ⅱ评分具有相关性;检测PCT水平联合APACHE Ⅱ评分对脓毒症病情及预后判断具有指导价值。 Objective To investigate the value of serum procalcitonin (PCT) combined with APACHE Ⅱ score in the treatment of sepsis. Methods Sixty-eight patients with sepsis in the Fourth Hospital of Changsha City, Sepsis were divided into sepsis group, severe sepsis group and septic shock group according to the severity of the disease. Serum PCT was detected in each group and APACHE Ⅱ score, PCT and APACHE Ⅱ correlation analysis. And then divided into survival group and death group according to the different prognosis of patients, evaluating the value of PCT, APACHE Ⅱ score in judging the prognosis of sepsis. Results The PCT of sepsis group was lower than that of severe sepsis group and severe sepsis group was lower than that of septic shock group (P <0.05). PCT and APACHE Ⅱ scores of death group were significantly higher than those of severe sepsis group Survival group, the difference was statistically significant (P <0.05). Conclusions There is a correlation between PCT level and APACHE Ⅱ score in sepsis patients. The detection of PCT level combined with APACHE Ⅱ score has guiding value for the sepsis condition and prognosis.