保罗样激酶1表达对胃癌的生物学行为及预后判定的意义

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目的 探讨保罗样激酶1(plk1)在胃癌组织中的表达情况以及与胃癌临床病理指标、患者预后的关系.方法 采用免疫组织化学回顾检测plk1在89例切除胃癌组织中的表达,分析其与胃癌临床病理学指标的关系;并分析plk1表达与患者生存的关系.结果 plk1在胃癌组织中的阳性率为42.7%(38/89),明显高于邻近非癌组织的13.5%(12/89)(P<0.01).plk1基因表达与胃癌的分化程度、浸润深度、TNM分期密切相关(P<0.05).plk1表达阳性患者的预后明显较阴性患者差(P<0.05).结论 plk1基因可能在胃癌发生发展中起促进作用,其过表达程度可作为胃癌的某些生物学行为及判定预后的新的参考指标.
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