论文部分内容阅读
子痫前期是妊娠期特有的孕20周后出现的血压升高、全身多脏器或系统发生改变甚至胎盘-胎儿受累的综合征,其发病机制尚不完全明确,对母儿的危害巨大,特别是对母体肾脏的损害严重,极易发生肾小球内皮损伤、基底膜增厚和系膜细胞增生,造成肾脏滤过屏障功能障碍和大量蛋白尿、足细胞尿,甚至可能导致母体远期肾脏功能不全。本文针对子痫前期患者肾脏的结构和功能损害的临床和基础研究进行综述,加深对子痫前期肾损害的发生机制和病理生理的认识,为进一步加强对肾损害的预测和干预的研究提供理论基础。
Preeclampsia is unique to pregnancy gestational 20 weeks after the emergence of elevated blood pressure, systemic multiple organ or system changes or placenta-fetal involvement syndrome, the pathogenesis is not yet fully clear, a tremendous harm to the mother and child, In particular, the damage to the mother’s kidney is serious and prone to glomerular endothelial injury, thickening of the basement membrane and mesangial cell proliferation, resulting in renal filtration barrier dysfunction and a large number of proteinuria, podocyte urine, and even may lead to long-term maternal Renal insufficiency. This review summarizes the clinical and basic research on the structural and functional impairment of the kidneys in preeclampsia and deepens the understanding of the pathogenesis and pathophysiology of renal damage in preeclampsia and provides a theoretical basis for further strengthening the research on the prediction and intervention of renal damage basis.