【摘 要】
：
In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1-7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp.brach
【机 构】
：
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc
论文部分内容阅读
In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1-7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp.brachystachys by solid data acquired by diverse methods.Among them,compound 3 with an ECs0 value of 4.3 pM against the chloroquine-resistant Plasmodiumfalciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than artemisinin.This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.
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