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目的了解惠东地区儿童呼吸道流感嗜血杆菌感染流行病学特征及耐药性,以期做好早期防治。方法分析2013年1月1日-2015年12月30日惠东县人民医院收治的1 112例儿童呼吸道感染患者资料,对其中105例流感嗜血杆菌感染进行流行病学特征总结并分析其耐药性情况。结果 1 112例呼吸道感染中有105例流感嗜血杆菌感染,占9.44%。105例流感嗜血杆菌儿童年龄以2~4岁儿童常见,占58.10%,以冬春季好发,占全部病例80.95%;流感嗜血杆菌β-内酰胺酶阳性有31例,其中对头孢曲松、头孢呋辛钠、阿奇霉素、头孢哌酮舒巴坦耐药性均较低,对左氧氟沙星、环丙沙星、氨苄西林、青霉素耐药较高,均大于50%;HI生物学分布上均以Ⅱ、Ⅲ最常见,共有60例,占全部的57.14%。结论2013-2015年儿童呼吸道流感嗜血杆菌感染以2~3岁儿童多见,好发于冬春季,常见于Ⅱ、Ⅲ生物分型,对阿奇霉素、第二、三代头孢菌素类抗生素敏感性较好。
Objective To understand the epidemiological characteristics and drug resistance of Haemophilus influenzae in children in Huidong area so as to make early prevention and treatment possible. Methods The data of 1 112 cases of children with respiratory tract infection admitted to Huidong County People’s Hospital from January 1, 2013 to December 30, 2015 were analyzed. The epidemiological characteristics of 105 cases of Haemophilus influenzae were summarized and analyzed. Medical conditions. Results Among 112 cases of respiratory tract infection, 105 cases of Haemophilus influenzae infection accounted for 9.44%. 105 cases of Haemophilus influenzae children aged 2 to 4 years old, accounting for 58.10%, with winter and spring, accounting for 80.95% of all cases; Haemophilus influenzae β-lactamase positive in 31 cases, of which cefotiam Cefuroxime sodium, azithromycin, cefoperazone sulbactam were lower resistance to levofloxacin, ciprofloxacin, ampicillin, penicillin resistance were higher, were greater than 50%; HI biological distribution are With Ⅱ, Ⅲ the most common, a total of 60 cases, accounting for 57.14% of all. CONCLUSIONS: Haemophilus influenzae infection in children from 2013 to 2015 is more common in children aged 2-3 years and occurs in winter and spring, and is common in type II and III of the genotyping. The susceptibility to azithromycin, the second and third generation cephalosporin antibiotics better.