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为了寻找中国人群强直性脊柱炎 (ankylosingspondylitis ,AS)的易感基因位点 ,采用全基因组扫描法对 9个强直性脊柱炎家系进行基因分型、参数连锁分析和非参数连锁分析。在参数连锁分析中 ,D6S2 76位点的最大LOD值为 3 882 1(θ =0 0 ) ,精细分析显示距D6S2 76位点附近的D6S1691和D6S1618的LOD值分别为 1 5717(θ =0 1)及2 0 0 56(θ =0 1)。在非参数连锁分析中 ,位于D6S2 76附近的LOD值高达 5 0 62 3 ,非参数连锁分析的NPL值为3 7561,最小P值为 0 0 0 0 2 3 3。上述结果提示 ,D6S2 76与强直性脊柱炎之间存在较强的连锁关系 ,D6S1691 D6S2 76 D6S1618区域可能存在强直性脊柱炎的易感基因位点。此外 ,D3S12 92、D4S153 5和D18S64的最大LOD值分别为1 2 768(θ =0 2 )、1 12 46(θ =0 2 )和 1 1851(θ =0 1) ,提示这些标记与AS之间存在一定的连锁关系
In order to search for susceptibility loci of ankylosponsive ankylosing spondylitis (AS) in China, genotyping, parametric linkage analysis and non-parametric linkage analysis of nine ankylosing spondylitis pedigrees were performed by genome-wide scan. In the parameter linkage analysis, the maximum LOD value of D6S2 76 locus is 3 882 1 (θ = 0 0). The detailed analysis shows that the LOD values of D6S1691 and D6S1618 near 76 loci of D6S2 are respectively 1 5717 (θ = 0 1 ) And 2 0 0 56 (θ = 0 1). In non-parametric linkage analysis, the LOD value was around 5662 in the vicinity of D6S276, the NPL value in non-parametric linkage analysis was 37,561, and the minimum P value was 0 0 0 0 2 3 3. The above results suggest that there is a strong linkage between D6S2 76 and ankylosing spondylitis, and there may be susceptibility loci for ankylosing spondylitis in D6S1691 D6S2 76 D6S1618. In addition, the maximum LOD values for D3S12 92, D4S153 5 and D18S64 are 1 2 768 (θ = 0 2), 1 12 46 (θ = 0 2) and 1 1851 (θ = 0 1), respectively, There is a certain chain between