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本文报导香菇多糖注射液对狗、大白鼠、小白鼠的急性毒性、亚急性毒性实验。急性毒性实验结果;小白鼠尾静脉注射LD_(50)及95％可信限为15O0(1061～212O)mg/kg。肌肉注射对狗的呼吸、血压、心电图均无明显影响。首次静脉注射均有迅速—过性降压作用,同时伴有快速耐受现象,这种降压效应部分可被大剂量异丙嗪所阻断。亚急性毒性实验结果:表明其对动物的心脏、肾脏功能无明显影响,对血清谷丙转氨酶明显下降。病理检查肝细胞有浊肿、水样变性,大剂量组偶有点状坏死,但在停药25天后肝细胞病理改变基本恢复。电子显微镜检查结果肝细胞超微结构基本正常。
This article reports the leptin polysaccharide injection of dogs, rats, mice acute toxicity, subacute toxicity experiments. The results of acute toxicity test showed that the LD_ (50) and 95% confidence limits of mice were intravenous injection of 15O0 (1061 ~ 212O) mg / kg. Muscle injection on the dog’s breathing, blood pressure, ECG had no significant effect. The first intravenous injection has a rapid - transient hypotensive effect, accompanied by rapid tolerance phenomenon, this antihypertensive effect of some high-dose promethazine can be blocked. Subacute toxicity test results show that: the animal’s heart and kidney function had no significant effect on serum alanine aminotransferase decreased significantly. Pathological examination of hepatocytes with turbidity, watery degeneration, high-dose group occasionally necrosis, but the pathological changes in liver cells recovered almost 25 days after the withdrawal. Electron microscopy results of liver cell ultrastructure was normal.