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目的探讨化疗对恶性肿瘤患者的临床疗效及对术后出现中性粒细胞减少的分析。方法分析72例恶性肿瘤患者的临床疗效及化疗中性粒细胞减少情况。结果化疗后随访,无瘤生存48例(66.7%),复发24例(33.3%);无中性粒细胞缺乏17例(23.6%),有中性粒细胞缺乏55例(76.3%),其中I度12例(16.7%),Ⅱ度25例(34.7%),Ⅲ度11例(15.3%),IV度7例(9.7%)。与无中性粒细胞组比较,Ⅰ度、Ⅱ度、Ⅲ度、IV度组,感染发生率均显著增高,P<0.05,P<0.01,P<0.001。结论化疗治疗对肿瘤的复发起一定控制作用,化疗过程中易出现中性粒细胞减少症,导致患者院内感染发生增加,临床上要加强对中性粒细胞的监控。
Objective To investigate the clinical efficacy of chemotherapy in patients with malignant tumors and the analysis of postoperative neutropenia. Methods 72 patients with malignant tumor clinical efficacy and chemotherapy neutropenia. Results After chemotherapy, 48 patients (66.7%) survived without disease and 24 patients (33.3%) relapsed. Neutropenia was found in 17 patients (23.6%) and neutropenia was found in 55 patients (76.3%), of which, I degree in 12 cases (16.7%), degree Ⅱ in 25 cases (34.7%), degree Ⅲ in 11 cases (15.3%), degree IV in 7 cases (9.7%). Compared with non-neutrophilic granulocyte group, the incidence of infection in grade Ⅰ, grade Ⅱ, grade Ⅲ, and grade IV were significantly increased, P <0.05, P <0.01, P <0.001. Conclusions Chemotherapy can restrain the recurrence of tumor. Neutropenia is easy to occur in the course of chemotherapy, leading to the increase of nosocomial infection and monitoring of neutrophils clinically.