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目的:研究冰冻单采血小板与冷沉淀联合输注在治疗产后大出血患者中的疗效。方法:选择输血量>2000ml的产后大出血患者随机分组,将冰冻单采血小板或冷沉淀单独输注者与联合输注者作了对比观察。观察指标输注前及输入后1～2h患者:①凝血酶时间(TT);②凝血酶原时间(PT);③活化部分凝血活酶时间(APTT);④纤维蛋白原(Fbg);⑤血小板计数PLT;⑥24h内有效止血率;⑦平均止血时间。结果:患者输注后1～2h比输前的TT、PT及APTT显著缩短,Fbg及ALT显著增加(P<0.01),平均止血时间为2.45±1.36h,24h止血有效率为96.15%。结论:在产后大出血患者输血治疗中,应用冰冻单采血小板组及冷沉淀联合输注有着显著的止血效果。
Objective: To study the curative effect of frozen apheresis combined with cryoprecipitate in the treatment of postpartum hemorrhage. Methods: Patients with postpartum hemorrhage of> 2000ml were randomly assigned to receive a comparison of cryoablated platelets or cryoprecipitate alone with those who received combined infusion. Patients were observed before and 1 to 2 hours after infusion: ① Thrombin time (TT); ② Prothrombin time (PT); ③ Activated partial thromboplastin time (APTT); ④ Fibrinogen (Fbg); ⑤ Platelet count PLT; ⑥ effective hemostasis within 24h; ⑦ average hemostasis time. Results: The TT, PT and APTT were significantly shortened and the Fbg and ALT were significantly increased (P <0.01). The average hemostasis time was 2.45 ± 1.36h and the hemostasis efficiency at 24h was 96.15%. Conclusion: In the treatment of postpartum hemorrhage in patients with transfusion, the application of frozen apheresis platelet and cryoprecipitate combined infusion has a significant hemostatic effect.