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子宫内膜异位症(endometriosis,EMs)指子宫内膜组织(腺体和间质)出现在子宫体以外的部位,具有痛经和不孕等相关症状。EMs患者不孕的发生率是正常人的20倍,EMs不孕患者总数占不孕患者总数也高达30%~50%[1]。因此,EMs不孕症在不孕中具有重要地位。许多学者在EMs不孕的患者子宫内膜中检测到同源盒(homebox,HOX)A10基因表达显著下调,其受DNA甲基化、mi RNA异常表达、组蛋白乙酰化等表达调控影响。本文从HOXA10基因的结构、功能以及表达调控与EMs
Endometriosis (endometriosis, EMs) refers to the endometrial tissue (glands and interstitial) in the uterus outside the body parts, with dysmenorrhea and infertility and other related symptoms. The incidence of infertility in patients with EMs is 20 times normal, and the total number of infertility patients with infertility EMs as high as 30% to 50% [1]. Therefore, EMs infertility plays an important role in infertility. Many scholars detect the down-regulation of A10 gene expression in the endometrium of patients with EMs infertility, which is influenced by the regulation of DNA methylation, abnormal expression of miRNA and histone acetylation. This article from HOXA10 gene structure, function and expression regulation with EMs