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目的 研究舒感颗粒的抗炎、抗菌、抗病毒及解热作用。方法 用流感病毒甲 3/京防 92 32 ,甲1/京防 86 1,甲 1/桂防 94 10等观察舒感颗粒的抗病毒活性。用金黄色葡萄球菌 ,肺炎链球菌 ,乙型溶血链球菌 ,流感杆菌 ,大肠杆菌及沙门菌观察舒感颗粒的抗菌作用。用二甲苯致小鼠耳肿胀和醋酸引起的小鼠腹腔渗出液 ,观察舒感颗粒的抗炎作用。用角叉菜胶给大鼠致热 ,观察舒感颗粒的解热作用。结果 舒感颗粒对流感病毒甲 3/京防 92 32 ,甲 1/京防 86 1,甲 1/桂防 94 10 ,对金黄色葡萄球菌 ,肺炎链球菌 ,乙型溶血链球菌 ,流感杆菌 ,大肠杆菌及沙门菌均有抑制作用。能显著地抑制二甲苯引起的小鼠耳肿胀和醋酸引起的小鼠腹腔渗出的炎症。对角叉菜胶引起大鼠体温升高有解热作用。结论 舒感颗粒具有抗炎、抗菌、抗病毒及解热作用。提示在临床上对感冒可能有标本兼治的功效。
Objective To study the anti-inflammatory, antibacterial, antiviral and antipyretic effects of Shugan granules. Methods The antiviral activity of Shugan granule was observed with influenza virus A/Jingjing 92 32, A/JP 86 1, A/JP 9410, etc. Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus b, Streptococcus influenzae, Escherichia coli, and Salmonella were used to observe the antibacterial effect of Shugan granules. Xylene-induced mouse ear swelling and acetic acid-induced peritoneal exudate in mice were used to observe the anti-inflammatory effects of Shugan granules. The rats were heated with carrageenan to observe the antipyretic effects of Shugan granules. Results Shugan granules against influenza virus A/Jingjing 92 32, A/Jingjing 86 1, A/1, Koufeng 94 10, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus b, Streptococcus flu, Both E. coli and Salmonella have inhibitory effects. It can significantly inhibit xylene-induced mouse ear swelling and acetic acid-induced inflammation in the abdominal cavity of mice. There is antipyretic effect on carrageenan-induced elevated body temperature in rats. Conclusion Shugan granules have anti-inflammatory, antibacterial, antiviral and antipyretic effects. Tips in the clinical treatment of colds may have the effect of treating both the symptoms and the causes.