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目的系统评价普萘洛尔治疗甲状腺功能亢进的有效性。方法计算机检索Pub Med、Em Base、Cochrane library、Clinical trials、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普和万方数据库,收集普萘洛尔治疗甲状腺功能亢进的随机对照临床试验,并进行文献质量评价和资料提取,用Rev Man 5.3进行Meta分析。结果共纳入12项随机对照临床试验,974例患者。Meta分析结果显示,与对照组相比,试验组能显著提高甲状腺功能亢进的有效率(P<0.01),显著降低游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平(P<0.01)。在促甲状腺激素(TSH)水平上,试验组和对照组差异无统计学意义(P>0.05)。结论普萘洛尔可提高甲状腺功能亢进治疗有效率,并改善甲状腺功能亢进患者体内甲状腺激素水平。
Objective To systematically evaluate the effectiveness of propranolol in the treatment of hyperthyroidism. Methods PubMed, Em Base, Cochrane library, Clinical trials, China Biomedical Literature Database (CBM), CNKI, VIP and Wanfang database were collected. Randomized controlled trials of propranolol in the treatment of hyperthyroidism Clinical trials, literature quality evaluation and data extraction, and Meta-analysis with Rev Man 5.3. Results A total of 12 randomized controlled clinical trials were included, 974 patients. Meta analysis showed that compared with the control group, the experimental group can significantly improve the efficiency of hyperthyroidism (P <0.01), significantly reduce the free triiodothyronine (FT3) and free thyroxine (FT4) levels (P <0.01). There was no significant difference in TSH between the experimental group and the control group (P> 0.05). Conclusion Propranolol can improve the efficiency of treatment of hyperthyroidism and improve thyroid hormone levels in patients with hyperthyroidism.