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目的 :探讨硒 (Se)和维生素E(VE)对糖尿病 (DM)大鼠红细胞膜流动性的影响 方法 :用链脲佐菌素 (STZ)制成DM大鼠模型并分为 4组 :( 1)DM对照组 ;( 2 )Se治疗组 ;( 3)VE治疗组 ;( 4 )Se+VE治疗组 ;另设正常对照组 ,每天以同体积生理盐水灌胃 一个月后 ,测定红细胞膜荧光偏振度(P)及糖化血红蛋白 (GHb)的含量 结果 :补充Se或 /和VE后 ,DM大鼠红细胞膜荧光偏振度显著下降 (P <0 0 5,P <0 0 1) ;GHb水平也明显下降 (P <0 0 1) ,它们之间呈显著正相关 结论 :Se和VE能增加DM大鼠红细胞膜流动性 ,这可能与它们抑制了葡萄糖和GHb的自动氧化有关
Objective: To investigate the effects of selenium (Se) and vitamin E (VE) on the erythrocyte membrane fluidity in diabetic rats.Methods: DM rats were induced by streptozotocin (STZ) and divided into 4 groups: 1) DM control group, (2) Se treatment group, (3) VE treatment group, (4) Se + VE treatment group, and another normal control group. One day after intragastric administration of normal saline, Fluorescence polarization (P) and glycated hemoglobin (GHb) content results: After Se or / and VE supplementation, the fluorescence polarization of erythrocyte membrane in DM rats decreased significantly (P <0.05, P <0.01) (P <0.01). There was a significant positive correlation between them. Se and VE increased the erythrocyte membrane fluidity in DM rats, which may be related to their inhibition of the auto-oxidation of glucose and GHb