【摘 要】
：
[61Cu]-labeled pyruvaldehyde-bis (N-4-methylthiosemicarbazone) (61Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the natZn(p,x)6
【机 构】
：
Nuclear Medicine Research Group,Department of Medical Physics
论文部分内容阅读
[61Cu]-labeled pyruvaldehyde-bis (N-4-methylthiosemicarbazone) (61Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the natZn(p,x)61Cu nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150μA irradiation for 76 min, about 6.006 Ci of 61Cu2+ was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. 61Cu-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [61Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors.
其他文献
Exact solution of the stress and velocity fields of a cylinder tube of metallic foams under inner Pressure is given in which the Triantafillou and Gibson consti
We study the problem of H∞ control for a class of Markovian jump systems with norm-bounded parameter uncertainties and mode-dependent mixed delays including di
Low valence vanadium oxide(VO2-x) thin films were prepared on SiO2/Si substrates at room temperature by direct current facing targets reactive magnetron sputter
This paper investigated several approaches to remapping and combining multiple-radar reflectivity fields onto a unified 3D Cartesian grid with high spatial and
Unsteady flows and rotating stall of a low-speed centrifugal compressor are investigated by measuring vaneless diffuser wall static pressure fluctuation and int
A multi-try counter-meshing gears (CMG) discrimination device based on micro electromechani-cal system (MEMS) technology was designed for some specified informa
This paper presents a novel ontology mapping approach based on rough set theory and instance selection.In this approach the construction approach of a rough set
Ni-TiN nanocomposite coatings were prepared by ultrasonic electrodeposition, and the effects of the surfactants on the coatings were investigated and the micros
Several bis(trifluoromethylsulfonyl)phenylamines have been synthesized and used as internal donors for the preparation of heterogeneous Ziegler-Natta catalysts